Amlodipine; Valsartan: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Articaine; Epinephrine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate.
Aspirin, ASA; Butalbital; Caffeine; Codeine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Aspirin, ASA; Carisoprodol; Codeine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Atracurium: Moderate Benzonatate may enhance the neuromuscular blocking action of nondepolarizing agents. Use caution during coadministration. Belladonna; Opium: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate.
Brompheniramine; Guaifenesin; Hydrocodone: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Brompheniramine; Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate.
Bupivacaine Liposomal: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate. Bupivacaine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate. Bupivacaine; Lidocaine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate. Calcium-channel blockers: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents.
Carbinoxamine; Hydrocodone; Phenylephrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Carbinoxamine; Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Chloroprocaine: Major Caution is advised if chloroprocaine is used concurrently with other local anesthetics. The toxic effects of the drugs are additive. Chlorpheniramine; Codeine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate.
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Chlorpheniramine; Hydrocodone: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Chlorpheniramine; Hydrocodone; Phenylephrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate.
Chlorpheniramine; Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Chlorthalidone; Clonidine: Moderate Epidural clonidine may prolong the duration of action of local anesthetics, including both sensory and motor blockade.
Cisatracurium: Moderate Benzonatate may enhance the neuromuscular blocking action of nondepolarizing agents. Clevidipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents.
Clonidine: Moderate Epidural clonidine may prolong the duration of action of local anesthetics, including both sensory and motor blockade. Cocaine: Moderate The actions of benzonatate could be additive to those of other local anesthetics. Codeine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Codeine; Guaifenesin: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate.
Codeine; Phenylephrine; Promethazine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate.
Codeine; Promethazine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Diltiazem: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents.
Diphenhydramine; Hydrocodone; Phenylephrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Doxacurium: Moderate Benzonatate may enhance the neuromuscular blocking action of nondepolarizing agents.
Enalapril; Felodipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Felodipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Guaifenesin; Hydrocodone: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate.
Guaifenesin; Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Homatropine; Hydrocodone: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Hydrocodone: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Hydrocodone; Ibuprofen: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate.
Hydrocodone; Phenylephrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Hydrocodone; Potassium Guaiacolsulfonate: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate.
Hydrocodone; Pseudoephedrine: Moderate The vagal effects and respiratory depression induced by hydrocodone may be increased by the use of benzonatate. Hydromorphone: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Isradipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Levobupivacaine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate.
Levorphanol: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Lidocaine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate.
Magnesium Salts: Moderate Because of the CNS-depressant effects of magnesium sulfate, additive central-depressant effects can occur following concurrent administration with local anesthetics.
Meperidine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Meperidine; Promethazine: Moderate The vagal effects and respiratory depression induced by opiate agonists may be increased by the use of benzonatate. Mepivacaine: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate.
Mepivacaine; Levonordefrin: Major Caution is advised if amide local anesthetics are used concurrently with benzonatate. Mivacurium: Moderate Benzonatate may enhance the neuromuscular blocking action of nondepolarizing agents. Monoamine oxidase inhibitors: Major These drugs should be prescribed with caution. It may be advisable to avoid the use of benzonatate, which is structurally similar to local anesthetic agents, in patients receiving a monoamine oxidase inhibitor MAOI.
Consider alternatives to benzonatate. If co-use is medically necessary, observe the patient for additive effects such as low blood pressure, sedation, dizziness, mental confusion, or other side effects. Neuromuscular blockers: Moderate Benzonatate may enhance the neuromuscular blocking action of nondepolarizing agents.
Nicardipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Nifedipine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. J Med Toxicol ; V Cohen et al. Cardiac arrest with residual blindness after overdose of Tessalon benzonatate Perles. J Emerg Med Nov 4 epub.
The Medical Letter on Drugs and Therapeutics. February 7, View Complete Issue. Drug Label Info. NDC National Drug Code - Each drug product is assigned this unique number which can be found on the drug's outer packaging. Hypersensitivity to benzonatate or related compounds. Hypersensitivity Severe hypersensitivity reactions including bronchospasm, laryngospasm and cardiovascular collapse have been reported which are possibly related to local anesthesia from sucking or chewing the capsule instead of swallowing it.
Psychiatric Effects Isolated instances of bizarre behavior, including mental confusion and visual hallucinations, have also been reported in patients taking TESSALON in combination with other prescribed drugs. Overdosage resulting in death may occur in adults. Nursing mothers It is not known whether this drug is excreted in human milk. Pediatric Use Safety and effectiveness in children below the age of 10 have not been established. Potential Adverse Reactions to TESSALON may include: Hypersensitivity reactions including bronchospasm, laryngospasm, cardiovascular collapse possibly related to local anesthesia from chewing or sucking the capsule.
GI: constipation; nausea; GI upset. Dermatologic: pruritus; skin eruptions. Deliberate or accidental overdose has resulted in death, particularly in children. Signs and Symptoms The signs and symptoms of overdose of benzonatate have been reported within 15—20 minutes.
Treatment In case of overdose, seek medical attention immediately. Do not use CNS stimulants. Adults and Children over 10 years of age Usual dose is one mg capsule three times a day as needed for cough. Petersburg, Florida Dist. Version Files Oct 14, 9 current download May 4, 8 download Nov 21, 7 download Jan 11, 6 download May 23, 4 download Aug 14, 3 download Jul 31, 2 download Feb 22, 1 download. NDC 1 Product Information. Inactive Ingredients.
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